QSAR Models for Reproductive Toxicity and Endocrine Disruption Activity
نویسندگان
چکیده
منابع مشابه
QSAR models for reproductive toxicity and endocrine disruption activity.
Reproductive toxicity is an important regulatory endpoint, which is required in registration procedures of chemicals used for different purposes (for example pesticides). The in vivo tests are expensive, time consuming and require large numbers of animals, which must be sacrificed. Therefore an effort is ongoing to develop alternative In vitro and in silico methods to evaluate reproductive toxi...
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A special challenge in the new European Union chemicals legislation, Registration, Evaluation and Authorisation of Chemicals, will be the toxicological evaluation of chemicals for reproductive toxicity. Use of valid quantitative structure-activity relationships (QSARs) is a possibility under the new legislation. This article focuses on a screening exercise by use of our own and commercial QSAR ...
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This report provides a state-of-the-art review of available computational models for developmental and reproductive toxicity, including Quantitative Structure-Activity Relationship (QSARs) and related estimation methods such as decision tree approaches and expert systems. At present, there are relatively few models for developmental and reproductive toxicity endpoints, and those available have ...
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Effects of endocrine disruptors on experimental animals and wildlife are well established. Antiandrogens and estrogens cause reproductive disorders, such as cryptorchidism, hypospadias, testicular dysgenesis and subfertility. This raises a natural question whether these disorders in humans are also caused by endocrine disrupters and whether they should alert us of harmful exposures. While we st...
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ژورنال
عنوان ژورنال: Molecules
سال: 2010
ISSN: 1420-3049
DOI: 10.3390/molecules15031987